Advanced Glycation End-Products Lead to Collagen Cross Link.
Advanced glycation end-products (AGEs) formation is a cross-linked complex of sugars and proteins. The accumulation of AGEs damages the adjacent proteins in a domino-like fashion and builds chemical bridges between collagen, leading to elastic lose, dullness and wrinkles in the skin. AGEs accumulation also generates Reactive Oxygen Species (ROS) and inflammatory factors that cause skin aging.
Discovered from Norway Picea Leaf and Pinaceae family plants live at high latitude and cold regions, FolinAGE X™ presented potent anti-glycation effects. It’s 30% more potent than Phloretin, and 8.5 times more potent than Apigenin, two famous anti-glycation actives. By blocking the formation of Methylglyoxal formation, a precursor of AGEs, FolinAGE X™ provides a novel way to prevent collagen crosslink and slow down the aging progress.