RESEARCH & INNOVATION
The Evidence Hub
Our commitment to scientific excellence is anchored in a vast body of peer-reviewed research. We don't just use ingredients; we discover them. Every product is a translation of longevity science from the laboratory to your skin.
With peer-reviewed publications and patents, our research leads the industry in autophagy induction, chronic inflammation (inflammaging), and DNA repair mechanisms.
Peer-Reviewed Research
Scientific Publications
Kinkéliba (Combretum micranthum) Leaf Extract Alleviates Skin Inflammation: In Vitro and In Vivo Study
Hu S, Simon JE, et al.
Molecules. 2023 28(4):1791. doi: 10.3390/molecules28041791
This study provides the first comprehensive in vitro and in vivo evidence of Kinkéliba's ability to neutralize chronic inflammatory markers. We identified its potential as a potent therapeutic agent for alleviating 'inflammaging,' leading to the development of our signature soothing complexes.
Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities
Welch C, Simon JE, Wu Q, et al.
Journal of Food and Drug Analysis. 2018 26(2):487-496. doi: 10.1016/j.jfda.2017.05.009
By identifying thirteen specific flavonoid compounds via spectrometric analysis, this research highlights the synergistic effects of Kinkéliba in reducing oxidative stress. These findings laid the groundwork for our understanding of how topical antioxidants can support skin metabolic health.
Rapid isolation of vitexin from leaves of kinkeliba, Combretum micranthum G. Don
Daba T, Simon JE, et al.
Journal of Pharmacognosy and Phytochemistry. 2021 10(1):14-16. doi: 10.22271/phyto.2021.v10.i1a.13251
This research established a breakthrough protocol for the high-purity isolation of Vitexin, a rare flavonoid. This ensures Acaderma's extracts meet pharmaceutical-grade standards for molecular consistency and potency.
Dietary polyphenols as photoprotective agents against UV radiation
Hu S, et al.
Journal of Functional Foods. 2016 30:108-118. doi: 10.1016/j.jff.2017.01.012
A critical review of how natural polyphenols shield skin cells from oxidative stress and DNA damage. This research informs our 'Photo-Resilience' strategy, moving beyond traditional SPF to internal cellular protection.
The Depigmenting Effect of Natural Resorcinol Type Polyphenols Kuwanon O and Sanggenon T from the Roots of Morus Australis
Hu S, et al.
The Journal of Ethnopharmacology. 2017 195:196-203. doi: 10.1016/j.jep.2016.11.020
We investigated Kuwanon O and Sanggenon T as non-toxic, natural alternatives to harsh brightening agents. This study proves that botanical resorcinols can effectively modulate melanin synthesis without compromising skin health.
Oxyresveratrol and trans-dihydromorin from the twigs of Cudrania tricuspidata as hypopigmenting agents against melanogenesis
Hu S, et al.
Journal of Functional Foods. 2015 13:375-383. doi: 10.1016/j.jff.2015.01.010
This research characterizes the mechanisms of action against melanogenesis, identifying high-performance botanical compounds that outperform standard synthetic brighteners in efficacy and stability.
Photoprotective Effects of Oxyresveratrol and Kuwanon O on DNA Damage Induced by UVA in Human Epidermal Keratinocytes
Hu S, et al.
Chemical Research in Toxicology. 2015 28(3):541-548. doi: 10.1021/tx500497u
Conducted on human epidermal keratinocytes, this study demonstrates how specific bioactives can actively protect and repair DNA integrity following UVA exposure, preventing the 'hallmarks of aging' before they appear.
Treatment of proteins with dietary polyphenols lowers the formation of AGEs and AGE-induced toxicity
Zhang X, Hu S, et al.
Food & Function. 2014 5(10):2656-2661. doi: 10.1039/c4fo00379a
Glycation is a primary driver of skin rigidity and yellowing. This study demonstrates how specific polyphenols inhibit the formation of Advanced Glycation End-products (AGEs), providing a roadmap for maintaining skin elasticity.
'Sweet Dani': A new culinary and ornamental lemon basil
Morales MR, Simon JE
HortScience. 1997 32(1):148-149
This publication introduces 'Sweet Dani', a new lemon basil cultivar developed for both culinary and ornamental applications. The cultivar offers enhanced aromatic properties and visual appeal for gardens and culinary use...
Evidence-Based Results
Clinical Trials
Kinkéliba Leaf Extract: Skin Irritation & Barrier Repair
Clinical Study: Mitigating Inflammaging and Chemical Stress
The Results: Evidence of Recovery
| Timeline | Barrier Repair (TEWL Reduction) | Redness Reduction (Erythema a* value) |
|---|---|---|
| Immediate | -20.95% | -4.19% |
| Day 3 | -49.96% | -10.77% |
| Day 7 | -59.81% | -22.40% |
* p < 0.05 vs placebo. All results demonstrate statistically significant recovery.
The Oasis Barrier Booster: Sensitivity & Hydration Resilience
Clinical Study: Calming Sensitive Skin and Strengthening the Moisture Barrier
The Results: Multi-Dimensional Soothing
| Timeline | Skin Hydration (Corneometry) | Sensitivity Reduction (Stinging Score) | Total Sensitivity Relief |
|---|---|---|---|
| Immediate | +36.88% | — | — |
| Day 14 | +46.55% | — | — |
| Day 28 | +56.33% | -56.76% | -50.70% |
* p < 0.001 vs baseline. All results are statistically significant.
Invisible Shield Defense Serum: Full-Spectrum Resilience
Clinical Study: Enhancing Skin's Natural Defense Against Environmental Stressors
The Results: Evidence of Protection
| Timeline | Result vs. Placebo | Significance |
|---|---|---|
| Redness Prevention | 83.33% Inhibition | p < 0.001*** |
| Erythema (a* value) | Significant Suppression | p < 0.001*** |
| Skin Threshold | Resilience up to 1.5 MED | p < 0.01** |
* p < 0.05 vs placebo. All results demonstrate statistically significant recovery.
Lunar Glow Illuminate Serum: Autophagy & Radiance
Clinical Study: Improving Surface Luminosity via Cellular Clearance
The Results: Restoring Natural Radiance
| Timeline | Day 56 Result | Significance |
|---|---|---|
| Skin Gloss (Luminosity) | +19.48% | p < 0.001*** |
| Spot Contrast (Waste Clearance) | Significant Decrease | p < 0.05* |
| Deep Hydration | 87% Agree | Consumer Sensation |
| Even Tone & Clarity | 81% Agree | Consumer Sensation |
* p < 0.05 vs placebo. All results demonstrate statistically significant recovery.
Key Insight:
- Self-Cleaning Mechanism: The serum triggers autophagy, the skin's natural way of clearing out 'biological waste' (broken proteins) that makes the complexion look dull and opaque.
- Light-Reflective Clarity: By purifying the cells from the inside out, the skin's surface becomes more uniform, leading to a 19.48% increase in visible gloss.
- Purified Tone: As cellular debris is removed, the contrast of dark spots decreases, resulting in a transparent, lit-from-within glow rather than a surface-level shine.
Chrono Warp Restoring Essence: Firmness & Wrinkle Reduction
Clinical Study: Elasticity & Structural Lift
The Results: Targeted Architecture Reconstruction
| Timeline | Timeline | Result | Significance |
|---|---|---|---|
| Skin Firmness (R0) | Week 4 | +11.29% | p ≤ 0.05* |
| Fine Lines & Wrinkles | Week 8 | -5.00% | p ≤ 0.05* |
| Laxity Improvement | Week 8 | 83.33% Agree | Consumer Sensation |
* p < 0.05 vs placebo. All results demonstrate statistically significant recovery.
Key Insight:
- Dermal Scaffolding: Starting at Week 4, the essence begins to rebuild the skin's resistance to pressure, measured as a significant increase in Firmness (R0).
- Surface Refinement: By Week 8, the rebuilding of the skin's internal support matrix results in a measurable smoothening of deep-set fine lines.
- Dynamic Lift: 83% of subjects observed a reduction in sagging, confirming that the structural rebuilding process translates into visible facial contour improvement.
Rainbow Radiance Face Oil: Firmness & Crow's Feet Recovery
Clinical Study: Instant Tension Lift & Biomechanical Firmness
The Results: Rapid Architecture Refinement
| Timeline | 15-Minute Result | Day 28 Result | Significance |
|---|---|---|---|
| Crow's Feet Count | -22.00% | -29.64% | p < 0.001*** |
| Crow's Feet Volume | -4.37% | -5.33% | p = 0.002** |
| Skin Radiance | — | +5.47% | p < 0.05* |
| Moisturization | — | 100% Agree | Consumer Sensation |
* p < 0.05 vs placebo. All results demonstrate statistically significant recovery.
Key Insight: The 'Tension Lift' Effect
- 15-Minute Flash Smoothing: The formula provides an instant tension lift, reducing visible wrinkle count by 22% almost immediately. This is achieved by reinforcing the lipid barrier and optimizing surface tension.
- Biomechanical Firmness (F₄): Clinical Cutometer® measurements showed a significant decrease in F₄ values, proving the skin has gained physical resistance and is firmer to the touch.
- Elasticity (R₂) Recovery: By Day 28, the skin demonstrates a restored "snap-back" ability. This confirms the oil provides long-term structural support rather than just a temporary visual effect.
- Total Tolerance: 100% of participants reported zero irritation, confirming that this high-active oil is safe for the delicate periocular (eye) area.
Better With Age Revival Light Cream: Longevity & Resilience
Clinical Study: Comprehensive Elasticity Restoration & Hydration Optimization
The Results: 100% Clinical Consensus
| Timeline | Clinical Result (D28) | Participant Consensus |
|---|---|---|
| Skin Hydration | +35.12%* | 100% Agree |
| Barrier Integrity (TEWL) | -7.87%* | 100% Agree |
| Skin Elasticity (R₂) | +6.63%* | 100% Agree |
| Skin Firmness (F₄) | +6.04%* | 100% Agree |
| Skin Radiance | +5.12%* | 100% Agree |
* p < 0.05 vs placebo. All results demonstrate statistically significant difference.
Key Insight: The Longevity Reset
- Universal Firmness Recovery: 100% of participants observed a tangible improvement in skin firmness, supported by a 6.04% clinical increase in biomechanical resistance. This confirms the formula's ability to combat the sagging associated with "inflammaging."
- NAD+ Powered Moisture: The 35.12% increase in hydration isn't just surface-level; it reflects a cell that has the energy (NAD+) to maintain its own internal water balance and structural barrier.
- Complete Fine Line Correction: The rare 100% agreement on wrinkle improvement proves that by quieting pro-inflammatory markers, the skin can finally focus its energy on rebuilding collagen and smoothing expression lines.
- High-Clarity Radiance: 100% of subjects reported improved radiance, correlating with the clinical reduction in TEWL (-7.87%), ensuring a healthy, non-opaque glow.
The Oasis Revival Mask: Acute Recovery & Hydration
Clinical Study: Intensive Moisture Infusion & Instant Redness Recovery
The Results: 15-Minute Rapid Stabilization
| Timeline | Treatment Result | Participant Consensus |
|---|---|---|
| Skin Hydration | +62.05%* | 96.77% Agree |
| Soothing Effect | Significant Recovery* | 96.77% Agree |
| Redness Improvement | Visible Reduction* | 96.77% Agree |
| Skin Smoothness | Improved Texture* | 96.77% Agree |
| Barrier Stability (TEWL) | -3.68%* | — |
* p < 0.001 denotes high statistical significance.
Key Insight: The Encapsulation Advantage
- Intensive Moisture Infusion: A 62.05% surge in hydration confirms high-efficiency delivery of humectants, instantly quenching dehydrated cells at a deeper level than standard topical masks.
- Instant Redness Recovery: 96.77% of participants reported an immediate reduction in redness. The formula stabilizes reactive skin, providing a "calm-on-contact" effect.
- Surface Micro-Refinement: Unlike traditional masks that only hydrate, the Encapsulated Salicylic Acid in Oasis provides a targeted smoothing effect. It gently refines the skin's grain, which is why 96.77% of users noted a physical difference in smoothness compared to baseline.
- Barrier Stability: The clinical reduction in TEWL proves the mask helps stabilize the skin's moisture seal, ensuring the recovery lasts long after the treatment is washed off.
Innovation & Intellectual Property
Proprietary Science & Patent Portfolio
Our research operates at the intersection of ethnobotanical wisdom and advanced molecular science. We hold a portfolio of international patents that protect our proprietary laboratory processes and novel molecular structures.
A Note on Ethical Innovation: Our patents represent our original scientific contributions—specifically the unique extraction, purification, and identification technologies developed in our labs. We do not patent plants or natural biological resources themselves; we respect the biodiversity and heritage of the regions and communities from which our ingredients are sourced.
Kinkeliba Anti-Inflammation Amplification Technology
The Innovation:
A proprietary extraction and purification method (not the plant itself) designed to amplify the natural anti-inflammatory efficacy of Kinkeliba.
The Benefit:
Targeted suppression of "inflammaging" signals at the source, neutralizing the chronic, low-grade inflammation that accelerates biological aging.
Novel Alkaloid Isolation (Piperidine Flavan) purification technology from kinkeliba
The Innovation:
Advanced methods for the separation and identification of a novel class of piperidine flavan alkaloids discovered within Kinkeliba.
The Benefit:
Harnesses rare, high-potency molecules that remain biologically unavailable in standard, unrefined extracts, providing superior structural skin resilience.
Autophagy Induction & Cellular Recycling
The Innovation:
A novel molecular structure that acts as a potent inducer of autophagy—the skin's natural "cellular cleanup" process.
The Benefit:
Directly supports the Longevity of the Lunar Glow Illuminate Serum. By helping cells clear out damaged proteins and oxidized debris, it restores clarity and health from the inside out.
Sesame-Derived Photoprotection
The Innovation:
A unique molecular composition of sesame extracts optimized for enhanced biological defense against UV-induced damage.
The Benefit:
Provides an essential layer of biological protection, reinforcing the skin's natural UV resilience and defending against photo-aging at a cellular level.
Our Scientific Commitment
We move beyond standard industry "claims" by securing legal and scientific recognition for our work. By transforming innovative technologies from academia, we ensure our technology remains at the forefront of global cosmetic science, offering you exclusive access to the future of skin longevity.
