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Ingredients Innovation,
Better Efficacy
Learn about Acaderma patented platform to innovate & validate ingredient that combat skin aging.
Clean Intelligence Quality.
Novel Ingredient Screening & Evaluation System
To develop more novel, better efficacy and safer ingredients, we don’t rely on ingredient suppliers. Acaderma Labs develop proprietary technologies that evolved out of our deep understanding of active ingredients and the science behind them.
1000+
compounds
100+
compounds
10+
compounds
1
Validated Ingredient
Clinical
Study
Our dermatologist co-founder established rigorous safety and efficacy evaluation standard for Acaderma. All products are skin patch tested via third party testing centre, and the safety & efficacy was evaluated by random, double-blind clinical trials. None of our products or ingredients are tested on animals.
Ingredients
Sourcing
We travel all corners of the globe in search of yet-unharnessed botanicals, and use column chromatography purification & identification technologies to discover novel plant polyphenols and their derivatives through bioassay-guided identification, and study their structure-activity relationship to develop more derivatives.
Screening &
Mechanism Study
We established different skin cell model to evaluate the efficacy rigorously in large scale, and study the action mechanism (e.g. enzyme activity, mRNA expression, protein expression…) using molecular biology, genomics and proteomics technologies, which is rigorous as pharmaceutical development.
Delivery system &
Formulation Design
Single potent active is not enough for a premium formula. After understanding the physical and chemical properties, our chemist engineers innovate high-efficiency trans-epiderma deliver system using 3D artificial skin model, and design formula that is free of fragrance, dyes and other unnecessary ingredients while providing a luxurious sensory experience.
Clinical
Study
Our dermatologist co-founder established rigorous safety and efficacy evaluation standard for Acaderma. All products are skin patch tested via third party testing centre, and the safety & efficacy was evaluated by random, double-blind clinical trials. None of our products or ingredients are tested on animals.
Ingredients
Sourcing
We travel all corners of the globe in search of yet-unharnessed botanicals, and use column chromatography purification & identification technologies to discover novel plant polyphenols and their derivatives through bioassay-guided identification, and study their structure-activity relationship to develop more derivatives.
“as founder, I patriated ALL these steps!”
The Pioneering Ingredients
Through this system, we isolate and extract actives that are scientifically & clinically proven to target different skin concerns.
Known as the “invention”, SeH-Haw EX® (patent pending) discovered from kinekliba tea reduces redness, repairs the skin barrier, and combats inflammation that causes the breakdown of collagen and elastin. In human keratinocytes, Seh-Haw EX™ significantly enhances cell survival rate decreased by UV radiation. It also helps to reduce environmental factors generated cellular ROS/RNS and proinflammatory cytokine secretion, to provide multiple protection to the skin barrier.
Our Publications
1. Juliani, H. Rodolfo, James Simon, et al. "Quality and consumer studies in the USA of African herbal teas for the natural product industry development in sub-Sahara Africa." 2009. 403-420.
2. Juliani, H. Rodolfo, James Simon, et al. Chemistry and pharmacology of Kinkéliba (Combretum micranthum), a west African medicinal plant
DISCOVER STORY
Acaderma - The Road to Discovery
Watch Later Share
Our patented ingredient Prophagy® discovered from cherry tomato is a unique flavone. Prophagy® was found to scavenge Advanced Glycation End Products (AGEs) induced inflammation, which resulting wrinkles and fine lines. At the same concentration, Prophagy ® is 2.5 times as potent as Vitamin C in melanocytes, which helps to remove excessive melanin and restore skin radiance.
Rather than other traditional pathways, the amazing efficacy of Prophagy ® is mainly due to a novel mechanism called autophagy. Autophagy is a natural, regulated mechanism in cell to cleanse waste and recycle old parts, including inflammatory factors¹. The 2016 Nobel Prize for Physiology or Medicine was awarded to Dr. Yoshinori Ohsumi for his discoveries of the underlying the mechanism of autophagy ².
Reference
1. Hansen, Malene, David C. Rubinsztein, and David W. Walker. "Autophagy as a promoter of longevity: insights from model organisms." Nature Review Mol Cell Biol 19 (2018): 579-93.
2. The Nobel Prize in Physiology or Medicine (2016). Discoveries of Mechanisms for Autophagy. Retrieved 3 Oct 2016
HOW IT WORKS
Discover More Acaderma Ingredients Secrets
Our exclusive actives, together with other synergic scientifically-proven ingredients, build a long-lasting foundation for healthy, nourished, and luminous skin.
EXCLUSIVE
SEH-HAW EX™
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Kinkeliba Tea
Anti-Inflammatory
Rich in polysaccharides and polyphenols that soothe inflammation and redness.
EXCLUSIVE
PROPHAGY™
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Cherry Tomato
Glow Boosting
Increases radiance and targets fine lines using a unique autophagy inducer that is 2.5 times more potent than Vitamin C.
EXCLUSIVE
SESAHELIO™
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Sesame Seed
Antioxidant
A potent and long-lasting antioxidant that defends skin against free radicals and inflammation-inducing cytokines.
EXCLUSIVE
MELAMORIN™
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Mulberry Root
Reduces Hyperpigmentation
Brightens dark spots by inhibiting melanin synthesis using tran-dihydromorin, a polyphenol 5 times more potent than kojic acid.
EXCLUSIVE
FolinAGE X™
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Norway Spruce Leaf
Anti-Aging
Slows down the aging process by blocking the formation of advanced glycation end products (AGEs) and preventing collagen crosslink.
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Hyaluronic Acid
Plumps Fine Lines
Suitable for all complexions and climates, this natural substance holds 1000 times its weight in water to temporarily smooth skin.
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Jojoba Oil
Calming
A non-comedogenic oil that mimics the lipid content of skin for a soft and smooth complexion.
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Glycosaminoglycans
Maintains Collagen
Derived from seaweed, glycosaminoglycans inhibit the matrix metalloproteinase (MMP) enzymes that degrade and destroy the skin’s collagen network.
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Marshmallow Root
Brightening
Prevents intrinsic factors from stimulating melanocytes for a more even and luminous complexion.
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Blueberry
Fights Free Radicals
This antioxidant-rich fruit contains pterostilbene that helps target free-radicals and hyperpigmentation.
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Beta- glucan
Soothing & Rejuvenating
Derived from oats, this ingredient wraps skin with moisture while boosting firmness and elasticity.
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Tranexamic Acid
Treats Dark Spots
Smooths rough skin and treats acne scars, melasma, and other forms of hyperpigmentation
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Summer Snowflake
Prevents Oxidative Damage
Reduces wrinkles, smooths skin, and boosts skin’s natural defences by enhancing superoxide dismutase, an enzyme that combats oxidative damage.
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Brown Seaweed
Protects DNA
A potent anti-ager that defends skin against UVA/UVB exposure, inflammation, and MMP1.
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Retinol Complex
Anti-Wrinkle
Promotes collagen production to reduce the appearance of fine lines and wrinkles.
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Cactus Stem
Soothing
Hydrates and calms skin by blocking the release of stress markers from sensory nerve cells.
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Lecithin
Enhances Absorption
A natural lipid that binds water and oil together to restore skin’s barrier and prevent moisture loss.
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Niacinamide
Lightens Dark Spots
A derivative of vitamin B3 that prevents melanin from reaching the surface of the skin.
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Resveratrol
Combats Blue Light
A natural polyphenol derived from grapes that combats photodamage caused by blue light and UV-radiation.
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Ceramide Complex
Strengthens Skin Barrier
A family of lipid molecules that protects skin barrier and helps skin retain moisture.
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Licorice Root
Radiance Booster
An anti-microbial and anti-inflammatory extract that targets dark spots by inhibiting the tyrosinase enzyme that controls melanin production.
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Japanese Knotweed
Antioxidant
A potent natural extract that soothes inflammation, battles bacteria, and helps even skin tone.
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Peptide Complex
Firming
Smoothes wrinkles and Lifts sagging skin by significantly increasing the synthesis of major constituents of dermal-epidermal junction.
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Diglucosyl Gallic Acid
Enhances Glow
Activated by the skin’s microbiome, this molecule alleviates inflammation and evens skin tone.
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Carnosine
Protects Collagen
Reduces fine lines and maintains skin’s barrier function by combatting oxidative damage and protecting collagen from glycation.
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Xylitylglucoside
Prevents Water Loss
Boosts hyaluronic acid and circulates moisture throughout every layer of skin.
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Vitamin B5
Skin Barrier Repair
Plant-derived provitamin B5 improves hydration, reduces transepidermal water loss, and maintains skin’s softness.
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Peony
Combats Pollution
Detoxifies, enhances radiance, and rejuvenates skin by removing damaged mitochondria.
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Alpha Lipoic Acid
Improves Skin Texture
An antioxidant that is proven to quench free radicals.
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Edelweiss Stem Cell
Lifting
Firms, lifts, and combats oxidative stress (air pollution, UV radiation, etc.).
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Allantoin
Reduces Redness
Helps alleviate irritation and moisturize skin.
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Cork Oak Bark
Smoothing
Contains suberin, a potent active clinically proven to lift and firm skin.
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Vitamin E
Antioxidant
Also known as tocopherol, this powerful vitamin combats the damaging effects of free radicals.
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Rice Bran
Evens Skin Tone
Reduces the appearance of dark spots by inhibiting tyrosinase activity during cellular melanogenesis.
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Olive Oil
Moisturizing
Rich in antioxidants, this natural ingredient softens skin and prevents dryness.