Longevity is
Multi-dimensional
At Acaderma, we believe a single-ingredient approach is insufficient to address the 14 distinct pathways of biological aging. We are biologists building the map between your skin's visible signs and their hidden cellular root causes.
Altered Intercellular Communication
Chronic Inflammation
Dysbiosis
Extracellular Matrix Changes
Stem Cell Exhaustion
Psychosocial Isolation
INFLAMMAGING
The Hidden Fire
Beneath Skin Aging
Chronic, low-grade inflammation — known as inflammaging — quietly accelerates biological aging. Over time, inflammatory cytokines disrupt collagen integrity, weaken the skin barrier, and trigger visible signs of aging.
Proprietary Bioactives
Our Solutions
Our research prioritizes interrupting the most aggressive drivers of rapid aging: Chronic Inflammaging—the "hidden fire" that weakens the skin barrier—and Disabled Macroautophagy, the "cellular recycling failure" that clutters your skin with biological waste. Backed by clinical trials and peer-reviewed publications, we utilize patented bioactives to target these specific hallmarks and help your skin shine from within.
SEH-HAW EX® is a high-potency concentrate derived from the Kinkéliba leaf, standardized to deliver a precise profile of bioactive molecules. This proprietary complex is rich in essential flavonoids—including Vitexin, Isovitexin, Orientin, Homoorientin, Myricetin-3-O-glucoside, and Myricetin-3-O-rutinoside—as well as alkaloids such as Stachydrine, Hydroxystachydrine, and Choline.
THE DATA
Breakthrough in Anti-Inflammaging Science
The patent SeH-Haw EX™ covers not the plant, but a breakthrough column-chromatography extraction and purification process engineered to isolate and concentrate the most potent anti-inflammatory fractions from Kinkéliba tea. This precision biotechnology enhances bioactive purity and stability, amplifying efficacy up to ten-fold compared with conventional extracts. The result is SeH-Haw EX™ - a next-generation active clinically proven to reduce redness, repair the skin barrier, and counteract inflammation that accelerates collagen and elastin breakdown.
Protein Levels of IL-6
(Inflammation Marker)
Protein Levels of IL-8
(Inflammation Marker)
Protein Levels of Nitrotyrosine
(Inflammatory Damage)
CLINICAL TRIAL
Proven Results, Visible Transformation
Our clinical studies demonstrate significant improvements in skin health markers, validated through rigorous scientific methodology.
Trans-epidermal water loss
after 7 days
Redness
after 7 days
Skin Hydration
after 28 days
Skin Sensitivity
after 28 days
Prophagy® targets cellular "recycling failure" by inducing autophagy— the mechanism honored by the 2016 Nobel Prize for Physiology or Medicine. When this pathway is impaired, biological waste and inflammatory factors accumulate, accelerating visible aging. Our in vitro data demonstrate that this patented flavone reactivates this critical housekeeping process, clearing debris to restore regenerative capacity at a cellular level.
THE DATA
Activating Cellular Self-Renewal
Prophagy® works by stimulating macroautophagy — the cell's built-in system for recycling damaged components. When this pathway is impaired, biological waste accumulates, accelerating visible aging. Our patented flavone complex reactivates this critical process, helping skin cells clear debris and restore their regenerative capacity.
Autophagy Detection
by Fluorescence Microscopy
Prophagy Increases ΔL Value
in Artificial Skin Model
CLINICAL TRIAL
Cellular Renewal, Visible Results
The measure of an autophagy inducer lies not just in subcellular repair, but in visible, high-definition results. Clinical studies confirm that Prophagy® delivers a significantly more radiant complexion and improved skin glow compared to the placebo group. After just 4 and 8 weeks of treatment, subjects demonstrated a measurable increase in luminosity, proving that clearing biological "clutter" leads to a statistically significant restoration of skin vitality.
Skin Gloss
after 56 days
Improved Skin Glow
subject perception
